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Yi-Pin Lin, Ph.D.

  • Yi-Pin Lin, Ph.D.

    Yi-Pin Lin, Ph.D.

    • Zoonotic Diseases

    • Ph.D., Cornell University
    • Postdoctoral training: Tufts University School of Medicine

    yi-pin.lin@health.ny.gov
    Office: 518-402-2233; Lab: 518-473-2789

Research Interests

Lyme disease, transmitted by the bacteria Borrelia burgdorferi, is the most common vector-borne disease in the U.S. The bacteria can infect at the site of the tick bite and then survive in the bloodstream and spread to the heart, joints, or brain, resulting arthritis, neurological abnormalities, and carditis. According to the Center of Disease Control and Prevention (CDC), approximate 30,000 people are infected annually, and most of them are in the Mid-west and Northeast states including New York State.

The research in my laboratory investigates the mechanisms of pathogen-host interactions. We are particularly interested in how the Lyme disease bacteria, Borrelia burgdorferi, survive in two distinct host environments (ticks and vertebrate hosts) by escaping from the killing of the complement system to cause transmission between hosts, dissemination, and diseases. Our goal is to identify and analyze the complement- or complement regulator-binding factors of B. burgdorferi, which facilitate the immune evasion, tissue colonization, and bloodstream survival in different hosts. The approach is to use genome-wide screens such as Transposon-sequencing technology (Tn-seq) to identify these factors and then test their contributions to the disease by using biochemical and genetic techniques and murine models. These factors could be targets to block the bacterial transmission between hosts. Illumination of the mechanisms employed by B. burgdorferi to interact with hosts will promote the development of prophylactic and therapeutic approaches to improve human health.

Select Publications

Tufts DM, Hart TM, Chen GF, Kolokotronis SO, Diuk-Wasser MA, Lin YP.
Outer surface protein polymorphisms linked to host-spirochete association in Lyme borreliae.
Mol Microbiol.
(2019)
(doi:10.1111/mmi.14209):
Marcinkiewicz AL, Dupuis AP 2nd, Zamba-Campero M, Nowak N, Kraiczy P, Ram S, Kramer LD, Lin YP.
Blood treatment of Lyme borreliae demonstrates the mechanism of CspZ-mediated complement evasion to promote systemic infection in vertebrate hosts.
Cellular Microbiology.
(2019)
Mühleip JJ, Lin YP, Kraiczy P.
Further Insights Into the Interaction of Human and Animal Complement Regulator Factor H With Viable Lyme Disease Spirochetes.
Front Vet Sci.
(2019)
5
(346):
Marcinkiewicz AL, Dupuis AP 2nd, Zamba-Campero M, Nowak N, Kraiczy P, Ram S, Kramer LD, Lin YP.
Blood treatment of Lyme borreliae demonstrates the mechanism of CspZ-mediated complement evasion to promote systemic infection in vertebrate hosts.
Cell Microbiol.
(2019)
21
(2):
e12998.
Chou E, Lin YP, Cady NC.
Recent strategies for the diagnosis of early Lyme disease.
Sci Prog.
(2018)
101
(4):
311-331.
Hart T, Nguyen NTT, Nowak NA, Zhang F, Linhardt RJ, Diuk-Wasser M, Ram S, Kraiczy P, Lin YP.
Polymorphic factor H-binding activity of CspA protects Lyme borreliae from the host complement in feeding ticks to facilitate tick-to-host transmission.
PLoS Pathog.
(2018)
14
(15):
e1007106.
Hart T, Yang X, Pal U, Lin YP.
Identification of Lyme borreliae proteins promoting vertebrate host blood-specific spirochete survival in Ixodes scapularis nymphs using artificial feeding chambers.
Ticks Tick Borne Dis.
(2018)
9
(5):
1057-1063.
Bernard Q, Smith AA, Yang X, Koci J, Foor SD, Cramer SD, Zhuang X, Dwyer JE, Lin YP, Mongodin EF, Marques A, Leong JM, Anguita J, Pal U.
Plasticity in early immune evasion strategies of a bacterial pathogen.
Proc Natl Acad Sci U S A.
(2018)
115
(16):
E3788-3797.