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Investigators and Program Directors

David A. Lawrence

David A. Lawrence

Research Scientist, Wadsworth Center, Immunology
Professor, School of Public Health, Biomedical Sciences and Environmental Health Sciences

Ph.D., Biochemistry, Boston College (1971)
Postdoctoral Training: Scripps Clinic and Research Foundation, Immunopathology (1974)

E-mail: david.lawrence@wadsworth.org

Research Interests

Our research addresses the biochemical and molecular analysis of the human and murine immune systems with specific emphasis on the mechanisms by which chemicals and drugs alter the structure/function of antigen-presenting cells and the T-lymphocyte subsets responsible for maintenance of the balance between cell-mediated and humoral (antibody-mediated) immune responses. The lymphocyte subsets are investigated to assess the qualitative and quantitative subcellular changes that occur with cell activation, growth, differentiation, functional responses, and cell death/apoptosis. We are especially concerned with the influence of oxidative stress from environmental toxicants and pathogens as well as aging on immune responsiveness. Modulations of immune responses by exogenous (environmental and dietary factors) and endogenous (hormonal and neural factors) regulators that can increase or decrease the incidence of infectious diseases, cancers and autoimmune diseases are being investigated along with the molecular genetic mechanisms responsible for the bidirectional generation of cytokines and neuropeptides by the immune system and the central nervous system.

An understanding of interorgan as well as lymphoid subset molecular communications is integral to unraveling the means by which immunity controls homeostasis and health. Our in vivo and in vitro models are designed to determine the mechanisms of the neuroendocrine immune network. Environmental stressors, including infections, induce biomarkers that modify immunity as well as behavior and our research aims to determine the responsible biomarkers as well as their mechanisms of action.

>> Select Publications

Contact Information

Phone: (518)402-5684
Fax: (518)-474-1412
E-mail: david.lawrence@wadsworth.org.