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Haixin Sui, Ph.D.

  • Haixin Sui

    Haixin Sui, Ph.D.

    • Cellular and Molecular Basis of Diseases - Primary Cilia
    • Assistant Professor, School of Public Health, Biomedical Sciences, Structural and Cell Biology

    • Ph.D., Dalian University of Technology, China (1996)
    • Postdoctoral training: Lawrence Berkeley National Laboratory

  • Microtubule doublets by combining cryo-electron tomography
    Microtubule doublets by combining cryo-electron tomography

Research Interests

Proteins or protein complexes function as parts of biological systems rather than as independent entities. Our research interests lie in understanding the molecular and structural basis of macromolecular assemblies in their functional context. In particular, we aim to develop mechanistic models that explain how component proteins integrate together and perform coordinated functions within their biological systems.

The core of our methodological approach relies on structural methods of cryo-electron microscopy (cryo-EM). These methods are utilized in combination with molecular, biochemical, and other biophysical or imaging techniques to study the structural architecture, functional mechanisms and regulation of macromolecular complexes in the biological systems of which they are a part.

We also have interests, driven by our research goals, in developing methods of specimen preparation and image processing for cryo-EM. The current focus of our research is on the assembly, maintenance, and regulation of primary cilia and their sensory functions that involve microtubule-based complexes and membrane proteins.

Select Publications

Sui H, Downing KH.
Molecular architecture of axonemal microtubule doublets revealed by cryo-electron tomography.
Nature.
(2006)
442
(7101):
475-478.
Kishchenko G, Danev D, Fisher R, He J, Hsieh C, Marko M, Sui H.
Effect of fringe-artifact correction on sub-tomogram averaging from Zernike phase-plate cryo-TEM.
Journal of Structural Biology.
(2015)
191
(3):
299-305.
Sui HX, Downing KH.
Structural Basis of Interprotofilament Interaction and Lateral Deformation of Microtubules.
Structure.
(2010)
18
(8):
1022-1031.
Sui H, Han BG, Lee JK, Walian P, Jap BK.
Structural basis of water-specific transport through the AQP1 water channel.
Nature.
(2001)
414
(6866):
872-878.
Li HL, Sui HX, Ghanshani S, Lee S, Walian PJ, Wu CL, Chandy KG, Jap BK.
Two-dimensional crystallization and projection structure of KcsA potassium channel.
Journal of Molecular Biology.
(1998)
282
(2):
211-216.