We study mechanisms of protein biosynthesis in bacterial and eukaryotic cells, with a goal to understand bacterial drug resistance and identify new drug targets, using biochemical and high-resolution 3D cryo-EM techniques.
The core's focus is next-generation sequencing (NGS) data analysis, research computing, phylogenomics, antibiotic resistance, and large-scale data mining, in support of the evolving needs of the research community and public health initiatives.
Dr. Chave serves as the Director of the Biochemistry Core as well as the Protein Expression Core.
Core personnel work along side investigators to develop imaging strategies and image analysis protocols needed to solve their research questions.
We use innovative molecular genomic approaches to address fundamental questions of mycobacterial biology. Our findings shed new light on the evolution and function of mycobacterial genomes, accelerating tuberculosis research.
The Transgenic and Gene Knockout Core produces and analyzes transgenic and gene knockout mice that can be used as animal models of human disease.
My specific area of expertise within the Bioinformatics Core is bacterial genomics, evolution and phylogeny.
My research focuses on clarifying the phylogenetic relationships among microbial organisms and understanding microbial genome evolution, including the contributions of horizontal gene transfer and endosymbioses to shaping genomes and accelerating adaptive evolution.