Pascal Lapierre, Ph.D.

Pascal Lapierre, Ph.D.

Bioinformatics and Statistics Core
Ph.D., University of Connecticut (2007)

Research Interests

As a member of the Bioinformatics Core, I am actively working on a multitude of projects, both research and clinical, involving whole genome and targeted sequencing of clinical pathogens. My specific area of expertise is centered on bacterial genomics, evolution and phylogeny. My work and interest in genomics started in the early days of complete genome sequencing, trying to comprehend how genomes evolve and change over time.  

At the Wadsworth Center, my research focuses on using next generation sequencing technologies for clinical diagnostics and surveillance.  In collaboration with the Bacteriology Laboratory, we are working on implementing new methodologies that will lead to more comprehensive and rapid diagnostics of tuberculosis infections as well as their associated antimicrobial resistance. We are also actively pursuing new protocols such as nanopore sequencing and detection of pathogens directly from clinical samples for surveillance and outbreak management.

Select Publications
Smith C, Halse TA, Shea J, Modestil H, Fowler RC, Musser KA, Escuyer V, Lapierre P. Assessing Nanopore sequencing for clinical diagnostics: A comparison of NGS methods for Mycobacterium tuberculosis. J Clin Microbiol. 2020; Oct 14 (JCM): 00583-20. DOI: 10.1128/JCM.00583-20
Shea J, Halse TA, Lapierre P, Shudt M, Kohlerschmidt D, Van Roey P, Limberger R, Taylor J, Escuyer V, Musser KA. Comprehensive whole-genome sequencing and reporting of drug resistance profiles on clinical cases of Mycobacterium tuberculosis in New York State. J Clin Microbiol. 2017; 55 (6): 1871-1882. DOI: 10.1128/JCM.00298-17
Lapierre P, Nazarian E, Zhu Y, Wroblewski D, Saylors A, Passaretti T, Hughes S, Tran A, Lin Y, Kornblum J, Morrison SS, Mercante JW, Fitzhenry R, Weiss D, Raphael BH, Varma JK, Zucker HA, Rakeman JL, and Musser KA. Legionnaires’ Disease Outbreak Caused by Endemic Strain of Legionella pneumophila, New York, New York, USA, 2015. Emerg Infect Dis. 2017; 23 (11): 1784–1791. DOI: 10.3201/eid2311.170308
Taylor AJ, Lappi V, Wolfgang WJ, Lapierre P, Palumbo MJ, Medus C, Boxrud D. Characterization of Foodborne Outbreaks of Salmonella enterica Serovar Enteritidis with Whole-Genome Sequencing Single Nucleotide Polymorphism-Based Analysis for Surveillance and Outbreak Detection. J Clin Microbiol. 2015; 53 (10): 3334-40. DOI: 10.1128/JCM.01280-15