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Pascal Lapierre, Ph.D.

Research Interests

As a member of the Bioinformatics Core, I am actively working on a multitude of projects, both research and clinical, involving whole genome sequencing. My specific area of expertise is centered on bacterial genomics, evolution and phylogeny.  My work and interest in genomics started in the early days of complete genome sequencing, trying to comprehend how genomes evolve and change over time.  

At the Wadsworth Center, my research focuses on using next generation sequencing technologies for clinical diagnostics and pathogens surveillance.  In collaboration with the Bacteriology laboratory, we are working on implementing new methodologies that will lead to more comprehensive and rapid diagnostics of tuberculosis infections as well as their associated antimicrobial resistance. We are also actively pursuing new protocols for surveillance and outbreak management of diverse pathogens such as Legionella, E. coli, Neisseria and Clostridium.

Select Publications

McGinnis JM, Cole JA, Dickinson MC, Mingle LA, Lapierre P, Musser KA, Wolfgang WJ.
Paracoccus sanguinis sp. nov., isolated from clinical specimens of New York State patients.
Int J Syst Evol Microbiol.
(2015)
65
(Pt 6):
1877-1882.
Maltz MA, Bomar L, Lapierre P, Morrison HG, McClure EA, Sogin ML, Graf J.
Metagenomic analysis of the medicinal leech gut microbiota.
Frontiers in Microbiology.
(2014)
(5):
151.
Lapierre P, Lasek-Nesselquist E, Gogarten JP.
The impact of HGT on phylogenomic reconstruction methods.
Briefings in Bioinformatics.
(2014)
15
(1):
79-90.
Williams D, Gogarten JP, Lapierre P.
Filling the gaps in the genomic landscape.
Genome Biol.
(2010)
11
(2):
103.
Lapierre P, Gogarten JP.
Estimating the size of the bacterial pan-genome.
Trends Genet.
(2009)
25
(3):
107-110.