The Wadsworth Center provides resources such as reagents, strains, software, etc. that are made available to the scientific community, either free or for a nominal fee.
Antibodies to Bats | William T. Lee, Ph.D.
There has been much recent interest in the role of bats as potential reservoirs for emerging zoonotic diseases. However, research to fully understand the interplay between bats and viruses has been hampered by a lack of specific reagents and assays to characterize the bat immune system and specific immune responses made by bats. To fill this gap, our group is working to develop bat-specific antibodies, bat cell lines, and assays of bat immunity. To date, we have generated several mouse monoclonal antibodies reactive with surface molecules on (North American) bat cells, primarily lymphocytes. Our current efforts are to identify the target molecules of these monoclonal antibodies. Further, we have generated and fully characterized a monoclonal antibody reactive with bat immunoglobulins and B lymphocytes. This reagent has shown utility for identification of B lymphocytes in tissues and immunoglobulin in bat body fluids. Additionally, this monoclonal antibody has been used to develop seroassays to measure bat immune responses to infectious agents.
Genome sequence data posted in the Wadsworth Center’s Interactive Genomic portal is viewed through an embedded JBrowse genome browser. JBrowse works with popular web browsers, such as Safari, Chrome, Firefox, and Internet Explorer. Functional genomic data are aligned with a reference genome of the studied bacterial species for an integrated display. The user can interact with JBrowse, deciding which data tracks to visualize, adjusting the coverage scales, and zooming or scrolling through the genome to focus on points of interest. Additional information for JBrowse can be found at jbrowse.org, and in the original citation “JBrowse: A next-generation genome browser.” Mitchell E. Skinner et al., Genome Res. 2009. 19:1630-1638.
Pathogenic Fungus Culture Collection | Sudha Chaturvedi, Ph.D.
The HRI/NYSDOH Mycology Collection consists of 4,500-5,000 strains representing over 200 Genera and 450 Species of well-characterized human and animal pathogenic fungi. These strains are from a variety of clinical sources, have passed a rigorous morphological and molecular evaluation and are under long-term storage in liquid nitrogen.
Our RNA Bioinformatics lab has been engaged in algorithms and software tool development for prediction of RNA secondary structure and their applications to regulatory non-coding RNAs, with a recent focus on microRNAs (miRNAs) and small bacterial RNAs (sRNAs). Our widely used Sfold software for RNA folding and application is available to the scientific community.
SPIDER (System for Processing Image Data in Electron microscopy and Related fields) allows a researcher to create a three-dimensional reconstruction of a sub-cellular particle or large molecule from a collection of electron micrographs of the object taken from different directions. Using cryo-electron microscopy these methods have allowed researchers to determine the 3D structures of several macromolecular complexes at near-atomic resolution. These methods also provide a way of studying the structure of such complexes in a more natural environment than is possible using X-ray crystallography and for studying conformational changes of molecular machines.
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