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McDonough Laboratory

  • Girardin RC, Bai G, He J, Sui H, McDonough KA. AbmR (Rv1265) is a novel transcription factor of Mycobacterium tuberculosis that regulates host cell association and expression of the non-coding small RNA Mcr11. Mol Microbiol. 2018;110(5):811-830.
  • Pubmed Web Address

  • Ranganathan, S., J. Cheung, M. Cassidy, C. Ginter, JD Pata and K.A. McDonough. Novel structural features drive DNA binding properties of Cmr, A CRP family protein in TB complex mycobacteria. Nucleic Acids Research. 2018;46(1):403-420.
  • Pubmed Web Address

  • Johnson, R.M. and K.A. McDonough. Cyclic nucleotide signaling in Mycobacterium tuberculosis: an expanding repertoire. Pathogens and Disease. 2018;76(5):
  • Pubmed Web Address

  • DeMott CM, Girardin R, Cobbert J, Reverdatto S, Burz DS, McDonough K, Shekhtman A. Potent inhibitors of Mycobacterium tuberculosis growth identified by using in-cell NMR-based screening. ACS Chem Biology. 2018;13(3):733-741.
  • Pubmed Web Address

  • Johnson RM, G. Bai, C.M. DeMott, N.K. Banavali, C.R. Montague, C. Moon, A. Shekhtman, B. VanderVen, K.A. McDonough. Chemical activation of adenylyl cyclase Rv1625c inhibits growth of Mycobacterium tuberculosis on cholesterol and modulates intramacrophage signaling. Mol Microbiology. 2017;105(2):294-308.
  • Pubmed Web Address

  • Ranganathan, S., G. Bai, A. Lyubetskaya, G.S. Knapp, M.W. Peterson, M. Gazdik, A.L. Gomes, J.E. Galagan and K.A. McDonough. Characterization of an unusual cyclic AMP-responsive transcription factor Rv1675c (Cmr) in TB complex mycobacteria: a global regulator with links to the DosR regulon. Nucleic Acids Research. 2016;44(1):134-151.
  • Pubmed Web Address