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David A. Lawrence, Ph.D.

  • David A. Lawrence

    David A. Lawrence, Ph.D.

    • Clinical and Experimental Endocrinology and Immunology
    • Professor, School of Public Health, Biomedical Sciences and Environmental Health Sciences

    • Ph.D., Biochemistry, Boston College (1971)
    • Postdoctoral training: Scripps Clinic and Research Foundation, Immunopathology (1974)
    (518) 402-5684
    Fax: (518)-474-1412

Research Interests

Our research addresses the biochemical and molecular analysis of the human and murine immune systems with specific emphasis on the mechanisms by which chemicals and drugs alter the structure/function of antigen-presenting cells and the T-lymphocyte subsets responsible for maintenance of the balance between cell-mediated and humoral (antibody-mediated) immune responses. The lymphocyte subsets are investigated to assess the qualitative and quantitative subcellular changes that occur with cell activation, growth, differentiation, functional responses, and cell death/apoptosis. We are especially concerned with the influence of oxidative stress from environmental toxicants and pathogens as well as aging on immune responsiveness. Modulations of immune responses by exogenous (environmental and dietary factors) and endogenous (hormonal and neural factors) regulators that can increase or decrease the incidence of infectious diseases, cancers and autoimmune diseases are being investigated along with the molecular genetic mechanisms responsible for the bidirectional generation of cytokines and neuropeptides by the immune system and the central nervous system.

An understanding of interorgan as well as lymphoid subset molecular communications is integral to unraveling the means by which immunity controls homeostasis and health. Our in vivo and in vitro models are designed to determine the mechanisms of the neuroendocrine immune network. Environmental stressors, including infections, induce biomarkers that modify immunity as well as behavior and our research aims to determine the responsible biomarkers as well as their mechanisms of action.

Select Publications

Mendoza A, Torres-Hernandez JA, Ault JG, Pedersen-Lane JH, Gao D, Lawrence DA.
Silica nanoparticles induce oxidative stress and inflammation of human peripheral blood mononuclear cells.
Cell Stress Chaperones.
Zhang YB, Gao DH, Kluetzman K, Mendoza A, Bolivar VJ, Reilly A, Jolly JK, Lawrence DA.
The maternal autoimmune environment affects the social behavior of offspring.
Journal of Neuroimmunology.
Heo Y, Zhang Y, Gao D, Miller VM, Lawrence DA.
Aberrant immune responses in a mouse with behavioral disorders.
PLoS One.
Mondal TK, Saha SK, Miller VM, Seegal RF, Lawrence DA.
Autoantibody-mediated Neuroinflammation: Pathogenesis of Neuropsychiatric Systemic Lupus Erythematosus in the NZM88 Murine Model.
Brain Behav Immun.
Emeny RT, Gao D, Lawrence DA.
Beta1-adrenergic receptors on immune cells impair innate defenses against Listeria.
J Immunol.