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David A. Lawrence, Ph.D.

  • David A. Lawrence

    David A. Lawrence, Ph.D.

    • Neuroimmunology and Immunotoxicology
    • Professor, School of Public Health, Biomedical Sciences and Environmental Health Sciences

    • Ph.D., Biochemistry, Boston College (1971)
    • Postdoctoral training: Scripps Clinic and Research Foundation, Immunopathology (1974)

    david.lawrence@health.ny.gov
    (518) 402-5684
    Fax: (518)-474-1412

  • Changes in immunity and prevalence of disorders over past century
    Changes in immunity and prevalence of disorders over past century

Research Interests

Our research addresses the biochemical and molecular analysis of the human and murine immune systems with specific emphasis on the mechanisms by which chemicals and drugs alter the structure/function of the developing and aging immune system and the mechanisms by which the immune and nervous systems bidirectionally regulate each other. The balance between cell-mediated and humoral (antibody-mediated) immune responses is studied with emphasis on the T cell and antigen-presenting cell subsets. The mechanistic influences of oxidative stress from environmental toxicants and pathogens on endocrine, immune, and nervous system responsiveness is investigated. Modulations of immune responses by exogenous (environmental and dietary factors) and endogenous (hormonal and neural factors) regulators that can increase or decrease the incidence of infectious diseases, cancers and autoimmune diseases are being investigated along with neuroimmune disorders such as autism.

An understanding of interorgan as well as lymphoid subset molecular communications is integral to unraveling the means by which immunity controls homeostasis and health. Our in vivo and in vitro models are designed to determine the mechanisms of the neuroendocrine immune network. Modifications during the highly susceptible perinatal period increase the prevalence of neuroimmune pathologies. Environmental stressors, including infections, induce biomarkers that modify immunity as well as behavior and our research aims to determine the responsible biomarkers and their mechanisms of action.

Select Publications

Mendoza A, Torrisi DM, Sell S, Cady NC, Lawrence DA.
Grating coupled SPR microarray analysis of proteins and cells in blood from mice with breast cancer.
Analyst.
(2016)
141
(2):
704-712.
Kremer JM, Lawrence DA, Hamilton R, McInnes IB.
Long-term study of the impact of methotrexate on serum cytokines and lymphocyte subsets in patients with active rheumatoid arthritis: correlation with pharmacokinetic measures.
RMD Open.
(2016)
2
(1):
e0002.
Mendoza A, Torres-Hernandez JA, Ault JG, Pedersen-Lane JH, Gao D, Lawrence DA.
Silica nanoparticles induce oxidative stress and inflammation of human peripheral blood mononuclear cells.
Cell Stress Chaperones.
(2014)
19
(6):
777-790.
Zhang YB, Gao DH, Kluetzman K, Mendoza A, Bolivar VJ, Reilly A, Jolly JK, Lawrence DA.
The maternal autoimmune environment affects the social behavior of offspring.
Journal of Neuroimmunology.
(2013)
258
(1-2):
51-60.
Heo Y, Zhang Y, Gao D, Miller VM, Lawrence DA.
Aberrant immune responses in a mouse with behavioral disorders.
PLoS One.
(2011)
6
(7):
e20912.
Mondal TK, Saha SK, Miller VM, Seegal RF, Lawrence DA.
Autoantibody-mediated Neuroinflammation: Pathogenesis of Neuropsychiatric Systemic Lupus Erythematosus in the NZM88 Murine Model.
Brain Behav Immun.
(2008)
22
(6):
949-959.
Emeny RT, Gao D, Lawrence DA.
Beta1-adrenergic receptors on immune cells impair innate defenses against Listeria.
J Immunol.
(2007)
178
(8):
4876-4884.