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Research & Development

Funded research projects

  • HIV Nucleic Acid Testing (NAT) Demonstration Project: The goal of this project is to study the feasibility and effectiveness of utilizing designated public health reference laboratories to provide HIV-1 RNA testing for other public health laboratories when needed to complete the CDC’s recommended HIV diagnostic testing algorithm. Sponsored by: Association for Public Health Laboratories, 8/1/12 to Present
     
  • Development of Next Generation Sequencing Methods for Hepatitis C Virus: The goal of this project is to develop next generation sequencing (NGS) and data analysis methods for hepatitis C virus (HCV) to provide more robust tools for tracking HCV transmission during outbreak investigations and in the surveillance setting. Sponsored by: Wadsworth Center/Health Research Inc., 1/1/14 to Present
     
  • National HIV Behavioral Surveillance Project:  The goal of this project is to provide HIV-1 Western blot testing for dried blood spot (DBS) specimens submitted by participants in the National HIV Behavioral Surveillance (NHBS) project.  Surveillance is conducted in rotating, annual cycles in three different populations at high risk for HIV: men who have sex with men (MSM), injection drug users (IDU), and heterosexuals at increased risk for HIV infection (HET).   Sponsored by: Centers for Disease Control and Prevention (CDC), June 2012 to Present
     
  • Supplemental HIV testing evaluation: The goal of this project was to evaluate the use of a HIV-1/HIV-2 immunoassay and HIV-1 nucleic acid test as an alternative to the Western blot for confirming HIV reactive screening test results.  The laboratory evaluation was performed on 315 de-identified blood samples that had inconclusive HIV test results at the originating laboratory. Sponsored by: Association for Public Health Laboratories, 10/18/10-6/30/11
     
  • Targeted surveillance of treatment resistant HIV in HIV-positive MSM in New York City: The goal of this study was to describe the prevalence of HIV drug resistance mutations among a cohort of HIV-positive men who have sex with men. Sponsored by: National Institute of Drug Abuse, subcontract, 05/04/07 – 05/31/08

Current assay development projects

  • Development of HIV-2 Nucleic Acid Testing using Droplet Digital PCR: The goal of this project is to use droplet digital PCR technology to develop and validate assays to detect and quantify HIV-2 RNA and DNA from clinical specimens.
     
  • Development of an HIV-2 drug resistance test: The goal of this project is to develop a sequence-based HIV-2 genotype test to identify antiretroviral drug resistance mutations to help monitor HIV-2 infected patients. 

Bloodborne Viruses

  • Wesolowski LG, Wroblewski K, Bennett SB, Parker MM, Hagan C, Ethridge SF, Rhodes J, Sullivan TJ, Ignacio-Hernando I, Werner BG, Owen SM. Nucleic acid testing by public health referral laboratories for public health laboratories using the U.S. HIV diagnostic testing algorithm. Clinical Virology. 2015;(65):6-10.
  • Pubmed Web Address

  • Styer LM, Miller TT, Parker MM. Validation and clinical use of a sensitive HIV-2 viral load assay that uses a whole virus internal control. Journal of Clinical Virology. 2013;58(suppl 1):E127-E133.
  • Pubmed Web Address

  • Sullivan TJ, Antonio-Gaddy MS, Richardson-Moore A, Styer LM, Bigelow-Saulsbery D, Parker MM. Expansion of HIV screening to non-clinical venues is aided by the use of dried blood spots for Western blot confirmation. Clinical Virology. 2013;(58):123-126.
  • Pubmed Web Address

  • Goldsamt LA, Clatts MC, Parker MM, Colon V, Hallack R, Messina MG. Prevalence of Sexually Acquired Antiretroviral Drug Resistance in a Community Sample of HIV-Positive Men Who Have Sex with Men in New York City. AIDS Patient Care & Stds. 2011;25(5):287-293.
  • Pubmed Web Address

  • Styer LM, Sullivan TJ, Parker MM. Evaluation of an alternative supplemental testing strategy for HIV diagnosis by retrospective analysis of clinical HIV testing data. Journal of Clinical Virology. 2011;52(Suppl 1):S35-S40.
  • Pubmed Web Address