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Pallavi Ghosh, Ph.D.

  • Pallavi Ghosh

    Pallavi Ghosh, Ph.D.

    • Mycobacterial Stress Response

    • Ph.D. Center for Cellular & Molecular Biology, Hyderabad, India
    • Postdoctoral training: University of Pittsburgh

    pallavi.ghosh@health.ny.gov


Research Interests

 

Research in the Ghosh laboratory focuses on the mechanisms of antibiotic resistance in M. abscessus, which is a rapidly emerging nontuberculous mycobacteria (NTM) in patients with Cystic Fibrosis and underlying lung damage.

Specific projects include:

  1. Systems level understanding of changes that accompany exposure of M. abscessus to antibiotics.
  2. Identification of effectors that confer unique profiles of drug resistance.
  3. Screening of small molecule libraries for inhibitors of identified targets.
  4. Study the role of biofilm formation on antibiotic resistance of M. abscessus.

We use a combination of bacterial genetics, biochemistry and high throughput genomic analysis to decipher mechanisms of drug resistance.

To learn more, please visit the Ghosh Laboratory.

Select Publications

Bowman J, Ghosh P.
A complex regulatory network controlling intrinsic multidrug resistance in Mycobacterium smegmatis.
Mol Microbiol.
(2014)
91
(1):
121-134.
Singh S, Ghosh P, Hatfull GF.
Attachment site selection and identity in Bxb1 serine integrase-mediated site-specific recombination.
PLoS Genetics.
(2013)
9
(5):
e1003490.
Ghosh P, Bibb LA, Hatfull GF.
Two-step site selection for serine-integrase-mediated excision: DNA-directed integrase conformation and central dinucleotide proofreading.
Proceedings of the National Academy of Sciences USA.
(2008)
105
(9):
3238-3243.
Ghosh P, Wasil LR, Hatfull GF.
Control of phage Bxb1 excision by a novel recombination directionality factor.
PLoS Biology.
(2006)
4
(6):
E186.
Ghosh P, Kim AI, Hatfull GF.
The orientation of mycobacteriophage Bxb1 integration is solely dependent on the central dinucleotide of attP and attB.
Molecular Cell.
(2003)
12
(5):
1101-1111.