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Research and Development

Applied Clinical Research

The laboratory conducts applied research to continually develop new platforms for fungal diagnostics, antifungal susceptibility/resistance patterns, and fungal typing.

Special Projects

  • Evaluation of MALDI-TOF-MS technology for yeast and mold identification
  • Development of real-time PCR assays for pathogenic molds and yeasts
  • Evaluation of molecular assays for fungal typing  
  • Fungal characterization from culture collection repository
  • Evaluation of commercially available tests/kits and in-house developed tests for antifungal susceptibility testing
  • Whole genome and transcriptome analyses of pathogenic fungi
  • Rajkumar SS, Li X, Rudd R J, Okoniewski JC, Xu J, Chaturvedi S, Chaturvedi V. Clonal Genotype of Geomyces destructans among Bats with White Nose Syndrome, New York, USA. Emerging Infectious Diseases. 2011;17(7):1273-6.
  • Pubmed Web Address

  • Highland MA, Chaturvedi S, Perez M, Steinberg H, Wallace R. Histologic and molecular identification of disseminated Histoplasma capsulatum in a captive brown bear (Ursus arctos). Journal of Veterinary Diagnostic Investigation. 2011;23(4):764-769.
  • Pubmed Web Address

  • Sidamonidze K, Peck MK, Perez M, Baumgardner D, Smith G, Chaturvedi V, Chaturvedi S. Real-Time PCR Assay for Identification of Blastomyces dermatitidis in Culture and in Tissue. Journal of Clinical Microbiology. 2012;50(5):1783-1786.
  • Pubmed Web Address

  • Ginocchio CC, Lotlikar M, Li X, Elsayed HH, Teng Y, Dougherty P, Kuhles DJ, Chaturvedi S, George KS. Identification of endogenous coccidioides posadasii contamination of commercial primary rhesus monkey kidney cells. Journal of Clinical Microbiology. 2013;51(4):1288-1290.
  • Pubmed Web Address

  • Ren P, Luo M, Lin S, Ghannoum MA, Isham N, Diekema DJ, Pfaller MA, Messer S, Lockhart SR, Iqbal N, Chaturvedi V. Multilaboratory testing of antifungal drug combinations against Candida species and Aspergillus fumigatus: utility of 100 percent inhibition as the endpoint. Antimicrob Agents Chemother. 2015;59(3):1759-66.
  • Pubmed Web Address

  • Ramesh M, Resnick E, Hui Y, Maglione PJ, Mehta H, Kattan J, Bouvier NM, LaBombardi V, Victor TR, Chaturvedi S, Cunningham-Rundles C. Phellinus tropicalis abscesses in a patient with chronic granulomatous disease. J. Clin. Immunology. 2014;(34):130-133.
  • Pubmed Web Address

Basic Research

The laboratory’s externally funded basic research is focused on understanding pathogenic mechanisms of Cryptococcus gattii and Pseudogymnoascus destructans, the etiologic agents of cryptococcosis in humans and animals, and white nose syndrome (WNS) in bats, respectively.

Special Projects: 

  • Cryptococcus gattii pathogenic mechanisms. What pathogen and host factors dictate dissemination of C. gattii to the brain and gut?
  • Pseudogymnoascus destructans epidemiology, pathogenesis and outbreak investigations.
  • Tool generation for psychrophilic fungi to understand how fungi thrive in cold conditions and what unique traits make them pathogenic.

Grant: National Science Foundation (NSF) – 05/15/2012 to 04/30/2016
Title: Transformation System for Psychrophilic Fungi

  • Ren P, Chaturvedi V, and Chaturvedi S. Carbon dioxide is a powerful inducer of monokaryotic hyphae and spore development in Cryptococcus gattii and carbonic anhydrase activity is dispensable in this dimorphic transition. PloS One. 2014;9(12):e113147.
  • Pubmed Web Address

  • Zhang T, Victor TR, Rajkumar SS, Li X, Okoniewski JC, Hicks AC, Davis AD, Broussard K, LaDeau SL, Chaturvedi S, Chaturvedi V. Mycobiome of the bat white nose syndrome affected caves and mines reveals diversity of fungi and local adaptation by the fungal pathogen Pseudogymnoascus (Geomyces) destructans. PloS One. 2014;9(12):e116149.
  • Pubmed Web Address

  • Byrnes EJ, Li WJ, Ren P, Lewit Y, Voelz K, Fraser JA, Dietrich FS, May RC, Chatuverdi S, Chatuverdi V, Heitman J. A Diverse Population of Cryptococcus gattii Molecular Type VGIII in Southern Californian HIV/AIDS Patients - art. no. e1002205. PLoS Pathogens. 2011;7(9):2205.
  • Pubmed Web Address

  • Chaturvedi V, Chaturvedi S. Cryptococcus gattii: a resurgent fungal pathogen. Trends in Microbiology. 2011;19(11):564-71.
  • Pubmed Web Address

  • Chaturvedi S, Rajkumar SS, Li X, Hurteau GJ, Shtutman M, Chaturvedi V. Antifungal testing and high-throughput screening of compound library against Geomyces destructans, the etiologic agent of geomycosis (WNS) in bats. PLoS ONE [Electronic Resource]. 2011;6(3):e17032.
  • Pubmed Web Address

  • Springer DJ, Ren P, Raina R, Dong Y, Behr MJ, McEwen BF, Bowser SS, Samsonoff WA, Chaturvedi S and Chaturvedi V. Extracellular fibrils of pathogenic yeast Cryptococcus gattii are important for ecological niche, murine virulence and human neutrophil interactions. PLoS ONE [Electronic Resource]. 2010;5(6):e10978.
  • Pubmed Web Address