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Research & Development

Research Projects:

  • Develop RNA based detection assays, such as transcription-mediated amplification for increased sensitivity and multiplex detection of parasites in complex specimens
  • Use of MALDI –TOF and next generation sequencing for species identification in parasitology
  • Generate a high resolution cryo-electron microscopy map of cytoplasmic ribosomes purified from Trypanosoma brucei
  • Develop a nucleic acid amplification based assay to differentiate Entamoeba histolytica from Entamoeba dispar in stool samples and to detect Entamoeba histolytica in liver specimens
  • Helminth identification utilizing conventional PCR and sequencing to aid in identification of helminth specimens; cytochrome oxidase I gene (also used in the Barcode of Life Database) is the most commonly used gene target
  • Pyrosequence to detect genetic mutations that are causal for, or associated with, drug resistance in Plasmodium falciparum and to evaluate the resistance patterns associated with specific populations or geographic locations

Parasitology

  • Hashem Y, Georges AD, Fu J, Buss SN, Jossinet F, Jobe A, Zhang Q, Liao HY, Grassucci RA, Bajaj C, Westhof E, Madison-Antenucci S, Frank J. High-resolution cryo-electron microscopy structure of the Trypanosoma brucei ribosome. Nature. 2013;494(7437):385-389.
  • Pubmed Web Address

  • Joseph JT, Purtill K, Wong SJ, Munoz J, Teal A, Madison-Antenucci S, Horowitz HW, Aguero-Rosenfeld ME, Moore JM, Abramowsky C, Wormser GP. Vertical transmission of Babesia microti, United States. Emerging Infectious Diseases. 2012;18(8):1318-1321.
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  • Pubmed Web Address

  • Teal AE, Habura A, Ennis J, Keithly JS, Madison-Antenucci S. A New Real-Time PCR Assay for Improved Detection of the Parasite Babesia microti. Journal of Clinical Microbiology. 2012;50(3):903-908.
  • Pubmed Web Address

  • Ennis JG, Teal AE, Habura A, Madison-Antenucci S, Keithly JS, Arguin PM, Barnwell JW, Collins WE, Mali S, Slutsker L, Dasilva A, Hwang J. Simian Malaria in a U.S. Traveler -- New York. Morbidity and Mortality Weekly Report . 2008;58(9):229-232.
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  • Hans J, Hajduk SL, Madison-Antenucci S. RNA-editing-associated Protein 1 Null Mutant Reveals Link to Mitochondrial RNA Stability. RNA. 2007;13(6):881-889.
  • Pubmed Web Address

  • Cirino NM, Tavakoli NP, Madison-Antenucci S, Egan C. Multiplex rtPCR in Microbiology. Real Time PCR in Microbiology: From Diagnosis to Characterization. Caister Academic Press. 2007;
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