Research in the Wade laboratory focuses on gene regulation and CRISPR-Cas immunity in a range of bacterial species.

Specific topics of interest include: 

  1. Regulation of transcription initiation and termination in Escherichia coli
  2. Regulation of virulence gene transcription in Salmonella enterica and Yersinia pestis 
  3. Mechanisms of CRISPR-Cas immunity in E. coli and S. enterica
  4. Translational regulation and small protein function in mycobacteria (in collaboration with the Derbyshire/Gray Laboratory)

Our research relies heavily on next-generation sequencing approaches for genome-scale and high-throughput analysis of gene regulation and CRISPR-Cas function.

Program Updates

biofilm

Targeting Bacterial Communication to Disarm a Dangerous Pathogen

Bacteria are often thought of as simple, solitary organisms, but many species can coordinate their behavior as a group, a process called quorum sensing. When enough bacteria accumulate in one place, they release and detect small chemical signals that trigger collective behaviors, including the production of toxins and other factors that make infections difficult to treat. 
Biofilm Plate Paczkowski Laboratory

National Institutes of Health Training Grant Awarded to University at Albany Supports Wadsworth Center Fellows

A National Institutes of Health (NIH) Training Grant (T32) titled “RNA Science and Technology in Health and Disease” was awarded to the University at Albany, State University of New York, for $1.8 million over the next five years to support seven RNA Fellows each year from the graduate education programs that comprise the RNA Institute.  
Seven Fellows

Seven Fellows, One Goal

Wadsworth Center has long been committed to providing the next generation of public health professionals with the necessary knowledge, skills and abilities.More than 300 students have made Wadsworth Center their summer home over the course of nearly 30 years through the National Science Foundation-funded Research Experience for Undergraduates (REU) Program.
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