Ojha Laboratory

Research Interests

We study mechanisms underlying mycobacterial persistence against antibiotics. We use biofilms as a growth model in our studies. Biofilms are formed by most microbes including mycobacteria, and are defined as surface-associated, 3D-organized, multicellular communities encapsulated by extracellular matrix.  We hypothesize that inherent heterogeneity in microenvironments of biofilms leads to the development of a specialized subpopulation of cells adapted to extreme nutritional and hypoxic stresses, and that these elite cells develop into persisters. For example, we have observed that zinc depletion in mycobacterial biofilms induce ribosome hibernation, leading to the development of drug tolerant persister cells.

Learn more about our projects and the people behind them. Visit our Projects and People page.

Join us!

We currently have an opening for a postdoctoral fellow to work on mycobacterial persistence. If you are interested in a specific research area on this topic please send your resume and a description of your research interests to Anil Ojha. 

Research Affiliate I (Post Doctoral) JR-0002327

Applications due 10/2/26

The Research Affiliate I will offer a stimulating opportunity for an ambitious individual to advance their post-doctoral research skills through research training in molecular microbiology and pathogenesis of Mycobacterium tuberculosis (Mtb) in a mouse model of infection. This will entail working with guidance by the Principal Investigator with increasing independence to design and execute experiments. The incumbent will be involved in experiments that deploy techniques of molecular genetics, flow cytometry, immunohistochemistry, and cell biology, specifically within the framework of a mouse model of Mtb infection. The duties of the Research Affiliate I will include the extensive handling of mice, infecting mice with Mtb, performing intrapulmonary delivery of drugs in Mtb-infected mice, and analyzing lung pathology of these mice. In this mentored position, the incumbent will manage the daily operation of the laboratory animal program that includes writing IACUC protocols, participating in routine Institutional Animal Care and Use Committee (IACUC)-related meetings, managing mouse breeding, and assisting with routine husbandry.

This position will be part of a dynamic team serving the Wadsworth Center’s mission in the New York State Department of Health’s efforts to protect and promote the health of New York’s citizens. Come be a part of Science in the Pursuit of Health®!