Research in the Wade laboratory focuses on gene regulation and CRISPR-Cas immunity in a range of bacterial species.
Specific topics of interest include:
- Regulation of transcription initiation and termination in Escherichia coli
- Regulation of virulence gene transcription in Salmonella enterica and Yersinia pestis
- Mechanisms of CRISPR-Cas immunity in E. coli and S. enterica
- Translational regulation and small protein function in mycobacteria (in collaboration with the Derbyshire/Gray laboratory)
Our research relies heavily on next-generation sequencing approaches for genome-scale and high-throughput analysis of gene regulation and CRISPR-Cas function.