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McDonough Laboratory

Research in the McDonough laboratory has a major focus on gene regulation in the context of bacterial pathogenesis, or the means by which bacteria cause disease. Bacteria need to modulate their gene expression to adapt to changing conditions during infection, which requires environmental sensing as well as gene regulatory factors. The team is primarily interested Mycobacterium tuberculosis, the bacterium that causes TB, Yersinia pestis, the etiologic agent of bubonic and pneumonic plague, and Staphylococcus aureus, which is best known for causing MRSA, or methicillin resistant S. aureus infections. The lab uses a variety of techniques in their studies with each pathogen, ranging from molecular genetics and biochemistry to next generation sequencing and bioinformatics as well as proteomics and microscopy.